The town has witnessed the rise and fall of various civilizations and cultures due to its strategic location near the river, which made it a significant point for trade and communication. Over the centuries, the region has been influenced by different empires, including the Mughals, the Sikhs, and the British, each of which left their mark on the local history.

In 1856, the drastic flood of Indus River devastated the whole city of Kot Mithan. The Britishers shifted the Tehsil Head Quarter to Rajanpur by abolishing Tehsil Kot Mithan through a notification. Mr. A.A Munro was the last Assistant Commissioner of Kot Mithan who also took over the charge of first Assistant Commissioner of Rajanpur Tehsil in 1856.

Mithan kot (مِٹھّن کوٹ) also known as Kot Mithan, is a city in Rajanpur District in Punjab, Pakistan. Mithan kot is located on the west bank of the Indus River, a short distance downstream from its junction with Panjnad River. Most of its inhabitants are Saraikis and Baloch. The city is noted for being the site of the tomb of the famous Sufi poet, Hazrat Khawaja Ghulam Farid (رحمۃ اللہ علیہ). Kot Mithan is also the land where all five main rivers of Pakistan merge.

It believed that Mithan Kot was founded by a man named Mithan Khan. Mithan Khan is one of the prominent personalities of the area became a devoted disciple of the Khawaja family. He crossed over the Indus and founded the town of Mithan kot.